توضیحات
2 ایمینوتیولان (Traut’s reagent) 500 ميليگرم كد I6256 كمپاني سيگما آلدريچ (ترمو ساينتفيك26101)
I6256 Sigma-Aldrich
2-Iminothiolane hydrochloride
≥98% (TLC), powder
Synonym: 2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent
- CAS Number 4781-83-3
- Empirical Formula (Hill Notation) C4H7NS · HCl
- Molecular Weight 137.63
- Beilstein/REAXYS Number 3620079
- MDL number MFCD00039013
- PubChem Substance ID 24896086
- NACRES NA.21
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General description
2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent,[2] is commonly employed to attach thiol groups to proteins and peptides.[1] Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.[3]
Application
2-Iminothiolane hydrochloride has been used in the synthesis of thiolated PEG (poly(ethylene glycol).[4] It may be used to synthesize PLA-SH (polyethylene glycol-thiol) and PLA-PEG-SH (polyethylene glycol–polylactic acid-thiol).[5]
Thiolating reagent for primary amines. Reacts at pH 7-10 by amidine bond to present free sulfhydryl. Useful in preparation of disulfide and/or thioether linked conjugates.
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assay ≥98% (TLC) form powder impurities ≤5% Free sulfhydryl groups mp 198-201 °C (lit.) solubility H2O: 100 mg/mL storage temp. 2-8°C
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